Title | Wide-field microscopy using microcamera arrays |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | DL Marks, SH Youn, HS Son, J Kim, and DJ Brady |
Journal | Progress in Biomedical Optics and Imaging Proceedings of Spie |
Volume | 8589 |
Date Published | 01/2013 |
Abstract | A microcamera is a relay lens paired with image sensors. Microcameras are grouped into arrays to relay overlapping views of a single large surface to the sensors to form a continuous synthetic image. The imaged surface may be curved or irregular as each camera may independently be dynamically focused to a different depth. Microcamera arrays are akin to microprocessors in supercomputers in that both join individual processors by an optoelectronic routing fabric to increase capacity and performance. A microcamera may image ten or more megapixels and grouped into an array of several hundred, as has already been demonstrated by the DARPA AWARE Wide-Field program with multiscale gigapixel photography. We adapt gigapixel microcamera array architectures to wide-field microscopy of irregularly shaped surfaces to greatly increase area imaging over 1000 square millimeters at resolutions of 3 microns or better in a single snapshot. The system includes a novel relay design, a sensor electronics package, and a FPGA-based networking fabric. Biomedical applications of this include screening for skin lesions, wide-field and resolution-agile microsurgical imaging, and microscopic cytometry of millions of cells performed in situ. © 2013 Copyright SPIE. |
DOI | 10.1117/12.2002860 |
Short Title | Progress in Biomedical Optics and Imaging Proceedings of Spie |