Title | Review of bio-optical imaging systems with a high space-bandwidth product |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | J Park, DJ Brady, G Zheng, L Tian, and L Gao |
Journal | Advanced Photonics |
Volume | 3 |
Issue | 4 |
Date Published | 07/2021 |
Abstract | Optical imaging has served as a primary method to collect information about biosystems across scales-from functionalities of tissues to morphological structures of cells and even at biomolecular levels. However, to adequately characterize a complex biosystem, an imaging system with a number of resolvable points, referred to as a space-bandwidth product (SBP), in excess of one billion is typically needed. Since a gigapixel-scale far exceeds the capacity of current optical imagers, compromises must be made to obtain either a low spatial resolution or a narrow field-of-view (FOV). The problem originates from constituent refractive optics-the larger the aperture, the more challenging the correction of lens aberrations. Therefore, it is impractical for a conventional optical imaging system to achieve an SBP over hundreds of millions. To address this unmet need, a variety of high-SBP imagers have emerged over the past decade, enabling an unprecedented resolution and FOV beyond the limit of conventional optics. We provide a comprehensive survey of high-SBP imaging techniques, exploring their underlying principles and applications in bioimaging. |
DOI | 10.1117/1.AP.3.4.044001 |
Short Title | Advanced Photonics |