Order of Magnitude Signal Gain in Magnetic Sector Mass Spectrometry Via Aperture Coding.

TitleOrder of Magnitude Signal Gain in Magnetic Sector Mass Spectrometry Via Aperture Coding.
Publication TypeJournal Article
Year of Publication2015
AuthorsEX Chen, ZE Russell, JJ Amsden, SD Wolter, RM Danell, CB Parker, BR Stoner, ME Gehm, JT Glass, and DJ Brady
JournalJournal of the American Society for Mass Spectrometry
Volume26
Start Page1633
Issue9
Pagination1633 - 1640
Date Published09/2015
Abstract

Miniaturizing instruments for spectroscopic applications requires the designer to confront a tradeoff between instrument resolution and instrument throughput [and associated signal-to-background-ratio (SBR)]. This work demonstrates a solution to this tradeoff in sector mass spectrometry by the first application of one-dimensional (1D) spatially coded apertures, similar to those previously demonstrated in optics. This was accomplished by replacing the input slit of a simple 90° magnetic sector mass spectrometer with a specifically designed coded aperture, deriving the corresponding forward mathematical model and spectral reconstruction algorithm, and then utilizing the resulting system to measure and reconstruct the mass spectra of argon, acetone, and ethanol. We expect the application of coded apertures to sector instrument designs will lead to miniature mass spectrometers that maintain the high performance of larger instruments, enabling field detection of trace chemicals and point-of-use mass spectrometry.

DOI10.1007/s13361-015-1178-y
Short TitleJournal of the American Society for Mass Spectrometry