Compressive mass analysis on quadrupole ion trap systems.

TitleCompressive mass analysis on quadrupole ion trap systems.
Publication TypeJournal Article
Year of Publication2014
AuthorsEX Chen, M Gehm, R Danell, M Wells, JT Glass, and D Brady
JournalJournal of the American Society for Mass Spectrometry
Start Page1295
Pagination1295 - 1304
Date Published07/2014

Conventionally, quadrupole ion trap mass spectrometers eject ions of different mass-to-charge ratio (m/z) in a sequential fashion by performing a scan of the rf trapping voltage amplitude. Due to the inherent sparsity of most mass spectra, the detector measures no signal for much of the scan time. By exploiting this sparsity property, we propose a new compressive and multiplexed mass analysis approach--multi Resonant Frequency Excitation (mRFE) ejection. This new approach divides the mass spectrum into several mass subranges and detects all the subrange spectra in parallel for increased mass analysis speed. Mathematical estimation of standard mass spectrum is demonstrated while statistical classification on the parallel measurements remains viable because of the sparse nature of the mass spectra. This method can reduce mass analysis time by a factor of 3-6 and increase system duty cycle by 2×. The combination of reduced analysis time and accurate compound classification is demonstrated in a commercial quadrupole ion trap (QIT) system.

Short TitleJournal of the American Society for Mass Spectrometry