Coded aperture x-ray diffraction imaging with transmission computed tomography side-information

TitleCoded aperture x-ray diffraction imaging with transmission computed tomography side-information
Publication TypeConference Paper
Year of Publication2016
AuthorsI Odinaka, JA Greenberg, Y Kaganovsky, A Holmgren, M Hassan, DG Politte, JA O'Sullivan, L Carin, and DJ Brady
Conference NameProgress in Biomedical Optics and Imaging Proceedings of Spie
Date Published01/2016
Abstract

© 2016 SPIE. Coded aperture X-ray diffraction (coherent scatter spectral) imaging provides fast and dose-efficient measurements of the molecular structure of an object. The information provided is spatially-dependent and material-specific, and can be utilized in medical applications requiring material discrimination, such as tumor imaging. However, current coded aperture coherent scatter spectral imaging system assume a uniformly or weakly attenuating object, and are plagued by image degradation due to non-uniform self-attenuation. We propose accounting for such non-uniformities in the self-attenuation by utilizing an X-ray computed tomography (CT) image (reconstructed attenuation map). In particular, we present an iterative algorithm for coherent scatter spectral image reconstruction, which incorporates the attenuation map, at different stages, resulting in more accurate coherent scatter spectral images in comparison to their uncorrected counterpart. The algorithm is based on a spectrally grouped edge-preserving regularizer, where the neighborhood edge weights are determined by spatial distances and attenuation values.

DOI10.1117/12.2216915